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Drug of the Viagra company Pfizer contains in the structure sildenafil. This active ingredient belongs to the class of inhibitors of phosphodiesterase-5 (FDE-5), means for treatment of erectile dysfunction. One tablet comprises 50 mg of a sildenafil.

The mechanism of effect of Viagra suppression sildenafil is the cornerstone of activity of FDE-5. It leads to prevention of disintegration of cGMF enzyme in cavernous bodies of a penis and to accumulation of this substance. As cGMF relaxes smooth muscles, increase in its concentration leads to expansion of a gleam of vessels. Thanks to increase in inflow of blood to a penis there comes the erection.

In the insignificant volume of FDE-5 is present at thrombocytes, walls of vessels and internals. At the expense of it, reception of a sildenafil is capable to reduce coagulability of blood, to prevent development of a vasospasm.

Viagra concerning phosphodiesterase-5 is much more active, in comparison with other FDE forms thanks to what has practically no impact on other bodies and systems. Linking of a sildenafil with FDE-6 can leads to disturbance of color perception.

Most often Viagra is applied at various disturbances of an erection for the purpose of improvement of filling improvement by blood of cavernous bodies of a penis.

Other indication for use of this drug – supertension in a small circle of blood circulation. Sildenafil promotes vasodilatation of the pool of a pulmonary artery, thereby reducing pulmonary hypertensia.

Treat absolute contraindications:

Individual intolerance of the sildenafil or Viagra;
Intake of nitrates.

As nitrates (nitroglycerine, isosorbide dinitrat, Isosorbide mononitrate and etc.) promote vasodilation, at simultaneous use of Viagra perhaps sharp falling of arterial blood pressure up to a loss of consciousness and a depressed case.

Viagra is capable to cause the following undesirable reactions:

Pains in the head;
Feeling of inflows of heat, face reddening;
Digestive disturbance;
Congestion of a nose;
Development of infections of urinary tract;
Change of color perception;
Dizziness;
Skin rashes;
Falling of arterial blood pressure;
Orthostatic hypotension;
Cardiopalmus.

Other side effects meet much less often.

Tablets of Viagra are dissolved in an oral cavity. It is not necessary to chew or swallow entirely them. To reach improvement of erectile function, Viagra should be accepted in 30 – 60 minutes prior to expected sexual intercourse. For this purpose put one tablet of drug on language and wait for its dissolution. Later you can wash down drug with a small amount of water.

If it is required to accept 100 mg of drug, then the second tablet should be used right after dissolution of the first.

It is not recommended to apply Viagra more often than 1 time a day. The maximum therapeutic dose – 100 mg.