Glucocorticoids – group of the steroid hormones emitted by bark of adrenal glands. They possess antiinflammatory, immunodepressive, antiallergic and many other types of activity, are used as replacement therapy at adrenal insufficiency and a wide range of other morbid conditions. Prednisone belongs to synthetic glucocorticosteroids.
Stabilizes cellular membranes, including lizosomal’s, reduces an exit of proteolytic enzymes from lysosomes (braking of a phase of alteration and restriction of the center of inflammation), inhibits A2 phospholipase, breaks a liberation of arachidonic acid and, as a result, synthesis of PG, oxyacid’s and leukotrienes oppresses, brakes activity of hyaluronidase and reduces permeability of capillaries (oppression of a phase of exudation), activity of fibroblasts (oppression of a phase of proliferation). Antiallergic properties are caused by disturbance of degranulation of mast cells, reduction of synthesis of leukotrienes and suppression of products of antibodies, antishock — a delay of sodium and water, increase in reaction of vessels on endo-and exogenous vasoconstrictive substances and the stimulating influence on warm activity, anti-toxic — acceleration of an inactivation of toxic agents in a liver, reduction of permeability of cellular membranes.
Drug is shown to use at the following diseases:
Bekhterev’s disease (ankylosing spondylitis);
Various allergic diseases;
Acute adrenal insufficiency;
Congenital hyperplasia of bark of adrenal glands (adrenogenital syndrome);
Different types of dermatitis;
System lupus erythematosus;
Prevention and treatment of shock of any etiology.
Prednisone cannot be applied at:
Individual intolerance of drug;
Canker of a stomach and duodenum;
Disease or Icenco-Cushing syndrome;
Tendency to a thrombogenesis;
High figures of arterial blood pressure;
General fungus diseases;
Tuberculosis in an active form;
Mental disorders with productive symptomatology.
Use of Prednisone can cause:
General decrease in immunity;
Increase in level of sugar of blood;
Nitrogen exchange disturbance;
Calcium loss by bones;
Necrosis of bones;
Lowering of the level рН gastric juice;
Digestive tract canker;
Decrease in level of potassium of blood;
A delay of sodium and water in an organism;
Peripheral hypostases of soft tissues;
Increase in level of arterial blood pressure;
Excessive coagulability of blood;
Body weight increase;
Failure of a female hormonal cycle;
Weakness of skeletal muscles;
Disturbance of functioning of bark of adrenal glands.